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My work covers theory and practical topics at the intersection of statistical learning and information theory. In particular, the focus is on high dimensional and complex problems, that are not amenable to traditional statistical methods and guarantees. At the same time, we also try to understand the fundamental limitations on when learning is possible, and how to characterize non-uniform learning. We also explore complexity in sampling, such as from slow mixing Markov processes (for example, obtaining news on very polarized topics on the Internet), and study how to interpret data from such sources. 

Currently my research program is funded by grants from the National Science Foundation, the Department of Energy as well as UH Manoa, and my latest work tries to reshape the way we think about some statistical problems. At a high level, consider the nature of scientific discovery. We keep refining theories as we see more data. The natural question therefore is---will the refinements ever end? Will it happen that at some point, we can make up our minds and say with confidence that our inference is good enough and no more data will change it substantially? 

Some of my research threads on the ECE page: are here. I lead the DESCARTES collaboration that looks at the application of AI to power, healthcare and education. With my colleagues, I am co-developing Alu, a pedagogy engine that quantifies and projects the instructor pedagogy in all student interactions.

I advise x96 projects, see here.

Students

PhD students currently working with me are:

  • Chris Manloloyo
  • Andre Shiu
  • Yixin Zhang

Publications and CV

There are a number of nuances to these broad perspectives outlined above, and our recent publications listed below summarize some of our results. A more complete list of publications is available via my CV here.

[1] A. Shiu, C. Manloloyo, N. Santhanam, and L. Zhu. Privacy-Enhanced Load Forecasting by Aligning Latent Distributions. IEEE Cyber Awareness and Research Symposium (CARS), 2026. Accepted. Preprint available here.

[2] H. Zhang, M. Zaeri-Amirani, M. Abolfazli, N. P. Santhanam, J. Zhang, A. Høst-Madsen, C. Kimata, J. C. Perry, and A. Bratincsak. Artificial Intelligence Enhanced Electrocardiogram Analysis for Age and Sex Classification in Youth. Pediatric Cardiology, 2026. Available online here.

[3] N. Santhanam and Y. Zhang. On Logistic Regression and Maximum Entropy Approaches. IEEE International Symposium on Information Theory (ISIT), 2025. Available online here. Preprint available here.

[4] A. Kuh, N. Santhanam, D. Port, L. Thompson, and M. Lee. A Novel Multidisciplinary Graduate Education Program in Data Science. International Joint Conference on Neural Networks (IJCNN), 2025. Available online here. Preprint available here.

[5] A. Høst-Madsen, M. Amirani, and N. Santhanam. A Bound for Learning Lossless Source Coding with Online Learning. International Symposium on Information Theory and Its Applications (ISITA), pages 64-69, 2024. Available online here.

[6] M. Hosseini and N. Santhanam. Tail Redundancy and its Characterization of Compression of Memoryless Sources. Journal of Selected Areas of Information Theory, 2023. Available online here.

[7] N. Santhanam, V. Anantharam, and W. Szpankowski. Data driven weak universal compression. Journal of Machine Learning Research, 2022. Available online here.

[8] C. Wu and N. Santhanam. Non-uniform consistency of online learning with random sampling. In Proceedings of the 32nd International Conference on Algorithmic Learning Theory, 2021. Available online here.

[9] C. Wu and N. Santhanam. Prediction with finitely many errors almost surely. In Proceedings of The 24th International Conference on Artificial Intelligence and Statistics, 2021. Available online here.

[10] C. Wu and N. Santhanam. Entropy property testing with finitely many errors’. In Proceedings of IEEE Symposium on Information Theory, Virtual conference due to covid-19, 2020.

[11] C. Wu and N. Santhanam. Almost uniform sampling from neural networks. In Proceedings of the 54th Annual Conference on Information Sciences and Systems, 2020.

Semester Number Title Times Location
Every semester eex96 Design Project Thu 2:30-3:30pm Holmes Hall 411
Fall 2026 ece342 Probability and Statistics 10:30-11:30 MWF Biomed T211
Fall 2026 ece 640 Random Processes 1:30-2:45pm Sakamaki C-101